Feedback regulation of S-adenosylmethionine decarboxylase synthesis.
نویسندگان
چکیده
Treatment of Ehrlich ascites-tumour cells with 1-amino-oxy-3-aminopropane (AOAP), a potent inhibitor of ornithine decarboxylase, resulted in a marked decrease in cellular contents of putrescine and spermidine, concomitant with an arrest of cell growth. The activity of S-adenosylmethionine decarboxylase (AdoMetDC) was greatly increased in cells treated with AOAP. This increase in AdoMetDC activity was shown to be, at least partly, caused by enhanced synthesis of the enzyme, which most likely was induced by the change in cellular polyamine content.
منابع مشابه
Translational regulation of the plant S-adenosylmethionine decarboxylase.
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S-Adenosylmethionine decarboxylase is a key enzyme for the synthesis of polyamines in mammals, plants and many other species that use aminopropyltransferases for this pathway. It catalyses the formation of S-adenosyl-1(methyl th io)-3-propylamine (decarboxyla ted S-adenosylmethionine), which is used as the aminopropyl donor. This is the sole function of decarboxylated S-adenosylmethionine. Its ...
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عنوان ژورنال:
- The Biochemical journal
دوره 257 3 شماره
صفحات -
تاریخ انتشار 1989